作者: Dieter Dr Palenschat , Ralph Dr Schmiechen , Gert Paschelke , Helmut Dr Wachtel , Wolfgang Dr Kehr
DOI:
关键词: 2-Pyrrolidone 、 Aryl 、 Organic chemistry 、 Alkoxy group 、 Halogen 、 Ring (chemistry) 、 Hydrocarbon 、 Chemistry 、 Medicinal chemistry 、 Alkyl 、 Saponification
摘要: 4-(Polyalkoxyphenyl)-2-pyrrolidones of the formula ##STR1## wherein R 1 and 2 each are hydrocarbon up to 18 carbon atoms at least one being other than methyl, a heterocyclic ring, or alkyl 1-5 substituted by halogen, OH, COOH, alkoxy, alkoxycarbonyl an amino group; R' is H, alkyl, aryl acyl; X O S; possess neuropsychotropic activity. The compounds can be produced saponifying decarboxylating corresponding 2-pyrrolidone-3-carboxylic acid ester cyclizing 3-phenyl-4-amino-butyric thereof. pyrrolidones converted thiopyrrolidones reaction with phosphorous pentasulfide in presence base.