4-(polyalkoxy-phenyl)-2-pyrrolidone ii

作者: Dieter Dr Palenschat , Ralph Dr Schmiechen , Gert Paschelke , Helmut Dr Wachtel , Wolfgang Dr Kehr

DOI:

关键词: 2-PyrrolidoneArylOrganic chemistryAlkoxy groupHalogenRing (chemistry)HydrocarbonChemistryMedicinal chemistryAlkylSaponification

摘要: 4-(Polyalkoxyphenyl)-2-pyrrolidones of the formula ##STR1## wherein R 1 and 2 each are hydrocarbon up to 18 carbon atoms at least one being other than methyl, a heterocyclic ring, or alkyl 1-5 substituted by halogen, OH, COOH, alkoxy, alkoxycarbonyl an amino group; R' is H, alkyl, aryl acyl; X O S; possess neuropsychotropic activity. The compounds can be produced saponifying decarboxylating corresponding 2-pyrrolidone-3-carboxylic acid ester cyclizing 3-phenyl-4-amino-butyric thereof. pyrrolidones converted thiopyrrolidones reaction with phosphorous pentasulfide in presence base.

参考文章(1)
Raymond Armand Linz, Joseph Honore Strubbe, Derivatives of 2-pyrrolidinone ,(1973)