The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease.

摘要: Virtually any neurological disorder leads to activation of resident microglia and invasion blood-borne macrophages, which are accompanied by an increase in number change phenotype astrocytes, a phenomenon generally termed reactive astrocytosis. One the functions attributed astrocytes is thought involve restoration tissue damage. Hitherto, role inflammatory reaction occurring Parkinson's disease has not received much attention. In present study, we examined events autopsies substantia nigra putamen from patients using age-matched normal as controls. nigra, was consistently observed all verified immunohistochemical detection CR3/43 ferritin. Activation putamen. No differences were between controls putamen, terms distribution, cellular density or morphology stained for glial fibrillary acidic protein metallothioneins I II, latter sharing high affinity metal ions known be induced possibly exert anti-oxidative effects. Together, these findings indicate that process characterized without astrocytosis, suggesting progressive loss dopaminergic neurons ongoing neurodegenerative with minimum involvement surrounding nervous tissue. The absence astrocytosis contrasts what follows virtually other may unique phenomenon.