Bifunctional stapled polypeptides and uses thereof
作者： Tom N. Grossmann , Gregory L. Verdine , Johannes Tsung-Han Yeh , Raymond E. Moellering , Youbean Oak
DOI:
关键词: Peptide 、 Effector 、 Linker 、 Chemistry 、 Bifunctional 、 Biomolecule 、 Biochemistry 、 Moiety
摘要: The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, linker moiety, and an effector that can be used tether, bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate bind biomolecule through the domain target domain. Polypeptides and/or polypeptide complexes are tethered by of invention, where bound peptide modifies alters peptide. Usesses inventive including methods for treatment disease cancer, inflammatory diseases) also provided.
google.ch 参考文章(351)
Marvin Burns, Pre-filled ampule and non-invasive hypodermic injection device assembly ,(1988)
Luca Scorrano, Stanley J. Korsmeyer, BID polypeptides and methods of inducing apoptosis ,(2002)
William Higgins, Ekkehard H. Bohme, Fritz Gerhart, Derivatives of 2,6-diamino-3-haloheptanedioic acid ,(1986)
Steven F. Peterson, Ampule filling device ,(1996)
Richard M. Jacoby, Intradermal injection device with medication and needle guard ,(1992)
R. C. Sheppard, E. Atherton, Solid phase peptide synthesis : a practical approach IRL Press. ,(1989)
James Ralph Hanson, Protecting Groups in Organic Synthesis ,(1999)
Sidney M. Hecht, Bioorganic chemistry : peptides and proteins Oxford University Press. ,(1998)
Ernest Ludwig Eliel, Samuel H. Wilen, Tables of resolving agents and optical resolutions ,(1972)
James S. Parsons, Needleless hypodermic jet injector ,(1995)