FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration.
作者： Yuqing Liu , Lizhao Guan , Jun Zhan , Danyu Lu , Junhu Wan
DOI: 10.1016/J.FEBSLET.2014.06.049
关键词: Integrin alpha M 、 Integrin 、 Chemistry 、 CD49c 、 Cell adhesion 、 Cell migration 、 Integrin, beta 6 、 Cell biology 、 Collagen receptor 、 FERM domain
摘要: Unconventional myosin VIIA (Myo7a) has been known to associate with hereditary deafness. Here we present a novel function of Myo7a by identifying that directly interacts integrin β5 subunit and regulates cell adhesion motility in an integrin-dependent manner. We found bound the cytoplasmic tail β5. Further, pinpointed integrin-binding domain at F3 first FERM F1 second domain. Functionally, Myo7a-induced migration were mediated αvβ5. These findings indicated selectively promotes αvβ5-mediated migration.
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