Amino Acid Transport during Muscle Contraction and Its Relevance to Exercise

作者: Michael J. Rennie , Sylvia Y. Low , Peter M. Taylor , Shihab E. O. Khogali , Pei-Chin Yao

DOI: 10.1007/978-1-4899-1928-1_27

关键词: Amino acidBiochemistryMyocyteGlutathioneChemistrySkeletal muscleGlutamineGlycogen synthaseMuscle contractionGlutamine transport

摘要: The functional significance of amino acid transport in skeletal muscle has been explored by the use a variety techniques including work isolated perfused organs, incubated organs and tissue culture cells. results suggest that although there is wide systems different characteristics with responses to ionic, hormonal nervous modulation, glutamine (transported system Nm) demonstrates some unusual properties not observed acids transported other systems. Glutamine at very high rates heart both glutamate transporter appear be adaptively regulated availability glutamine. appears involved regulation number important metabolic processes (e. g., glutathione reduced/oxidised ratio protein glycogen synthesis). Furthermore, interact for volume control many features attributable changes concentration modulated via alteration cytoskeletal status.

参考文章(12)
B. Mackenzie, A. Ahmed, M. J. Rennie, Muscle Amino Acid Metabolism and Transport Springer, Boston, MA. pp. 195- 231 ,(1992) , 10.1007/978-1-4899-1161-2_12
Sylvia Y. Low, Michael J. Rennie, Peter M. Taylor, Signaling elements involved in amino acid transport responses to altered muscle cell volume The FASEB Journal. ,vol. 11, pp. 1111- 1117 ,(1997) , 10.1096/FASEBJ.11.13.9367345
H S Hundal, M J Rennie, P W Watt, Characteristics of acidic, basic and neutral amino acid transport in the perfused rat hindlimb. The Journal of Physiology. ,vol. 408, pp. 93- 114 ,(1989) , 10.1113/JPHYSIOL.1989.SP017449
S Y Low, M J Rennie, P M Taylor, Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume. The Journal of Physiology. ,vol. 495, pp. 299- 303 ,(1996) , 10.1113/JPHYSIOL.1996.SP021594
Peter A. MacLennan, Kenneth Smith, Brian Weryk, Peter W. Watt, Michael J. Rennie, Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle FEBS Letters. ,vol. 237, pp. 133- 136 ,(1988) , 10.1016/0014-5793(88)80186-8
H S Hundal, M J Rennie, P W Watt, Characteristics of L‐glutamine transport in perfused rat skeletal muscle. The Journal of Physiology. ,vol. 393, pp. 283- 305 ,(1987) , 10.1113/JPHYSIOL.1987.SP016824
S Y Low, P M Taylor, M J Rennie, Responses of glutamine transport in cultured rat skeletal muscle to osmotically induced changes in cell volume. The Journal of Physiology. ,vol. 492, pp. 877- 885 ,(1996) , 10.1113/JPHYSIOL.1996.SP021353
A. Ahmed, D. L. Maxwell, P. M. Taylor, M. J. Rennie, Glutamine transport in human skeletal muscle American Journal of Physiology-endocrinology and Metabolism. ,vol. 264, ,(1993) , 10.1152/AJPENDO.1993.264.6.E993