The glucagonoma syndrome: Surgically curable diabetes

摘要: Abstract The glucagonoma syndrome associated with alpha-2 cell tumors of the islets Langerhans has emerged as a specific member apudoma tumor family. first case was described in 1942, and well documented 1966. There are now (including 3 reports presented herein) forty-seven cases literature, thirty appearing during past three years. Major features are: (1) diabetes mellitus; (2) characteristic skin lesions (necrolytic migratory erythema); (3) glossitis; (4) normochromic, normocytic anemia; (5) weight loss elevation plasma level immunoreactive glucagon. Of patients, 59.6 per cent female (28 47) aged twenty to seventy-three grow slowly, suggesting that early diagnosis surgical excision can be curative; however 59.1 (27 reported patients had extensive disease and/or hepatic metastases at time diagnosis. primary located body or tail (30 patients) head neck (4), remaining being “extensive” (12) not found (1). All on whom determinations were made (37) elevated glucagon levels tumor, between 0.3 96 ng/ml (normal here representative, one having localized resectable pancreas complete reversal symptoms return normal after operation, remote postresection period, third an nonresectable tumor. Increased awareness along improved technics localization have already produced promising trend toward earlier treatment this surgically curable type diabetes.