Structure-Based Docking Studies of GLUT4 Towards Exploring Selected Phytochemicals from Solanum xanthocarpum as a Therapeutic Target for the Treatment of Cancer

摘要: Background In recent years, there has been an exponential increase in the global burden of cancer which associated with several factors including environmental influence, aging, diet, infectious agents, hormonal imbalance and chronic inflammation, among others. Cancerous cells utilize more glucose for its proliferation survival than normal cells. Thus, regulation consumption cancerous through inhibition transporter-4-protein (GLUT4) encoded by solute carrier family-2-member-4-gene (Slc2a4) selected phytochemicals from Solanum xanthocarpum may serve as a new therapeutic candidate treatment cancer. Methods The seven identified potential inhibitors GLUT4 were retrieved PubChem database. Examination their drug-likeness, toxicity prediction molecular docking studies these compounds carried out using online tools such Molinspiration, PreADMET V.2.0 Patchdock server. Results findings revealed that, five fulfil oral drugability Lipinski's rule (RO5) while two slightly meet criteria RO5. Conversely, are predicted to be mutagen remaining safe body. Additionally, stigmasterol glucoside higher binding-affinity (7590) when compared doxorubicin (6600) control. Conclusion These suggest that could promising agent better efficacy via GLUT4.