Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.

摘要: The Ikaros zing-finger family transcription factors (IKZF TFs) are important regulators of lymphocyte development and differentiation also highly expressed in B cell malignancies, including Multiple Myeloma (MM), where they required for cancer growth survival. Moreover, IKZF TFs negatively control the functional properties many immune cells. Thus, targeting these proteins has relevant therapeutic implications cancer. Indeed, accumulating evidence demonstrated that downregulation Aiolos, two members family, malignant plasma cells as well adaptative innate lymphocytes, is key anti-myeloma activity Immunomodulatory drugs (IMiDs). This review focused on TF-related pathways MM. In particular, we will address how depletion exerts cytotoxic effects MM cells, by reducing their survival proliferation, concomitantly potentiates antitumor response, thus contributing to efficacy IMiDs, a cornerstone treatment this neoplasia.