Changes in Colorectal Carcinoma Genomes Under anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing
作者： Sumitra Mohan , Ellen Heitzer , Peter Ulz , Ingrid Lafer , Sigurd Lax
DOI: 10.1371/JOURNAL.PGEN.1004271
关键词: KRAS 、 Epidermal growth factor receptor 、 Polysomy 、 Cetuximab 、 Deep sequencing 、 Biology 、 Colorectal cancer 、 Whole genome sequencing 、 Cancer research 、 Panitumumab
摘要: Monoclonal antibodies targeting the Epidermal Growth Factor Receptor (EGFR), such as cetuximab and panitumumab, have evolved to important therapeutic options in metastatic …
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Jennifer S Lin, Elizabeth M Webber, Caitlyn A Senger, Rebecca S Holmes, Evelyn P Whitlock, Systematic review of pharmacogenetic testing for predicting clinical benefit to anti-EGFR therapy in metastatic colorectal cancer American Journal of Cancer Research. ,vol. 1, pp. 650- 662 ,(2011)
Ellen Heitzer, Martina Auer, Eva Maria Hoffmann, Martin Pichler, Christin Gasch, Peter Ulz, Sigurd Lax, Julie Waldispuehl‐Geigl, Oliver Mauermann, Sumitra Mohan, Gunda Pristauz, Carolin Lackner, Gerald Höfler, Florian Eisner, Edgar Petru, Heinz Sill, Hellmut Samonigg, Klaus Pantel, Sabine Riethdorf, Thomas Bauernhofer, Jochen B. Geigl, Michael R. Speicher, Establishment of tumor‐specific copy number alterations from plasma DNA of patients with cancer International Journal of Cancer. ,vol. 133, pp. 346- 356 ,(2013) , 10.1002/IJC.28030
Heidi Schwarzenbach, Dave S. B. Hoon, Klaus Pantel, Cell-free nucleic acids as biomarkers in cancer patients Nature Reviews Cancer. ,vol. 11, pp. 426- 437 ,(2011) , 10.1038/NRC3066
Alberto Bardelli, Pasi A Jänne, The road to resistance: EGFR mutation and cetuximab Nature Medicine. ,vol. 18, pp. 199- 200 ,(2012) , 10.1038/NM.2646
Andrea Bertotti, Giorgia Migliardi, Francesco Galimi, Francesco Sassi, Davide Torti, Claudio Isella, Davide Corà, Federica Di Nicolantonio, Michela Buscarino, Consalvo Petti, Dario Ribero, Nadia Russolillo, Andrea Muratore, Paolo Massucco, Alberto Pisacane, Luca Molinaro, Emanuele Valtorta, Andrea Sartore-Bianchi, Mauro Risio, Lorenzo Capussotti, Marcello Gambacorta, Salvatore Siena, Enzo Medico, Anna Sapino, Silvia Marsoni, Paolo M Comoglio, Alberto Bardelli, Livio Trusolino, None, A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discovery. ,vol. 1, pp. 508- 523 ,(2011) , 10.1158/2159-8290.CD-11-0109
Nicola Personeni, Steffen Fieuws, Hubert Piessevaux, Gert De Hertogh, Jef De Schutter, Bart Biesmans, Wendy De Roock, An Capoen, Maria Debiec-Rychter, Jean-Luc Van Laethem, Marc Peeters, Yves Humblet, Eric Van Cutsem, Sabine Tejpar, Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab : A fluorescent in situ hybridization study Clinical Cancer Research. ,vol. 14, pp. 5869- 5876 ,(2008) , 10.1158/1078-0432.CCR-08-0449
C Li, M Iida, E F Dunn, A J Ghia, D L Wheeler, Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene. ,vol. 28, pp. 3801- 3813 ,(2009) , 10.1038/ONC.2009.234
Clara Montagut, Alba Dalmases, Beatriz Bellosillo, Marta Crespo, Silvia Pairet, Mar Iglesias, Marta Salido, Manuel Gallen, Scot Marsters, Siao Ping Tsai, André Minoche, Somasekar Seshagiri, Sergi Serrano, Heinz Himmelbauer, Joaquim Bellmunt, Ana Rovira, Jeff Settleman, Francesc Bosch, Joan Albanell, Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer Nature Medicine. ,vol. 18, pp. 221- 223 ,(2012) , 10.1038/NM.2609
Alberto Bardelli, Simona Corso, Andrea Bertotti, Sebastijan Hobor, Emanuele Valtorta, Giulia Siravegna, Andrea Sartore-Bianchi, Elisa Scala, Andrea Cassingena, Davide Zecchin, Maria Apicella, Giorgia Migliardi, Francesco Galimi, Calogero Lauricella, Carlo Zanon, Timothy Perera, Silvio Veronese, Giorgio Corti, Alessio Amatu, Marcello Gambacorta, Luis A. Diaz, Mark Sausen, Victor E. Velculescu, Paolo Comoglio, Livio Trusolino, Federica Di Nicolantonio, Silvia Giordano, Salvatore Siena, Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer Cancer Discovery. ,vol. 3, pp. 658- 673 ,(2013) , 10.1158/2159-8290.CD-12-0558
F. Diehl, M. Li, D. Dressman, Y. He, D. Shen, S. Szabo, L. A. Diaz, S. N. Goodman, K. A. David, H. Juhl, K. W. Kinzler, B. Vogelstein, Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 16368- 16373 ,(2005) , 10.1073/PNAS.0507904102