Application of Monoclonal Antibodies to Autologous Bone Marrow Transplantation

摘要: A number of studies in animal models have suggested that serotherapy might be capable eliminating small numbers tumor cells vivo. Therapeutic activity has been documented using antisera against leukemias, lymphomas, and some solid tumors (Bernstein et al., 1982). However, for many years, trials human cancer limited by the lack availability sufficient amounts high-titered antiserum does not react with vital host tissues. Recently, success achieved treating mycosis fungoides other T-cell neoplasms heteroantisera reactive differentiation antigens (Fisher 1978). Anecdotal accounts noted responses after infusion alloantisera, but general had little demonstrable impact on most cancers