Triterpenoid saponins from the buds of Lonicera similis.
作者： Xiao Zhang , Li-Hua Zou , Yu-Lin He , Cheng Peng , Li Guo
DOI: 10.1080/14786419.2017.1408092
关键词: Cell culture 、 Lonicera similis 、 Betulinic acid 、 Hederagenin 、 Cytotoxic T cell 、 Chemistry 、 Apoptosis 、 Traditional medicine 、 Saponin 、 Oleanane
摘要: AbstractFour new lupane triterpenoid saponins, along with one known and eight hederagenin were isolated from the EtOH extract of buds Lonicera similis Hemsl. The structures compounds established as 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl 23-hydroxybetulinic acid 28-O-β-D-glucopyranosyl ester (lonisimilioside A, 1), 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl B, 2), betulinic C, 3) 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl D, 4), respectively. cytotoxic activities isolates against human cancer cell lines HepG2, MCF-7 A-549 evaluated. Only monodesmosidic saponin a free carboxyl group at C-28 (12) exhibited signific...
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