The relationship of CCR5 antagonists to CD4+ T-cell gain: a meta-regression of recent clinical trials in treatment-experienced HIV-infected patients.

摘要: AbstractPurpose: Lower CD4+ T-cell counts are related to increased morbidity and mortality despite virologic suppression. CCR5 antagonists associated with robust responses. We examined the relationship of gains. Design: Meta-regression recent phase 2–3 trials evaluating new antiretroviral agents in treatment-experienced subjects. Methods: analyzed count increase 24 weeks after initiating regimen using a linear model generalized estimating equations controlling for differing rates Each treatment group was treated as data point weighted by sample size. Results: included 46 groups from 17 (11 5 used antagonists). Controlling average baseline HIV-1 RNA proportion subjects achieving <50 copies/mL, use antagonist an additional significant gain +30/μL (95% CI,...