Phenotypic and functional dissection of myeloid-derived suppressor cells

摘要: Myeloid-derived suppressor cells (MDSCs) are originated and differentiated population from common hematopoietic progenitor cells. Generally, in the late stage of inflammation, MDSCs differentiation expansion promoted to suppress over-activated immune system so that can maintain homeostasis. Recently, it has been revealed accumulate cancer patients tumor-bearing experimental animals, these tumor-derived anti-tumor immunity by secreting immunosuppressive cytokines including reactive oxygen species inducible nitric oxide synthase. This fact prompts scientists shed light on as significant targets for anti-cancer immunotherapy. However, due morphological, phenotypic, functional heterogeneities MDSCs, is not easy develop therapeutic strategies targeting MDSCs. In this review, we will summarize recent progress defined subsets their T cell-mediated immunity.