Reactivation of Chagas' disease: cutaneous manifestations in two immunosuppressed patients.

摘要: Background  Chagas’ disease is a zoonosis caused by protozoan agent, Trypanosoma cruzi. Patients undergoing immunosuppressive treatment due to organ transplant, malignancies, infections, or chemotherapy may reactivate preexisting chronic indeterminate cruzi infection. Methods  We present two transplant patients who underwent reactivation of with cutaneous manifestations after an augmentation in their therapy. A 38-year-old man was hospitalized on day 69 receiving allogeneic bone marrow transplant; he developed multiple painful erythematous plaques diffuse borders, confined the right cheek, trunk, thigh, elbows, and feet. 59-year-old woman 14-year history Chagasic cardiomyopathy presented one month heart transplantation infiltrated purpuric plaque back her leg. Results  In both cases, histologic examination skin biopsies showed dermal infiltration intrahistiocytic amastigotes. one reported Strout method detected parasitemia. Treatments nifurtimox (600 mg/d) case 1 benznidazole (400 mg/d) 2 were started. Fever lesions resolved immediately seven days treatment. Conclusions  Reactivation serious complication that usually occurs immunocompromised patients. Clinical include febrile illness occasionally associated lesions. Early diagnosis proper can significantly improve these patients’ outcome.