Neuroendocrine Inherited or Induced Aromatase Enzyme Deficits

摘要: Publisher Summary This chapter explains how aromatase and hence estrogens play important roles in multiple physiological functions, from the development of genitalia to reproduction, metabolism, brain function behavior. Aromatase (CYP19) is a member cytochrome P450 superfamily. It found on endoplasmic reticulum membrane, forming complex with its co-enzyme/redox partner NADPH–cytochrome reductase. only known enzyme catalyze irreversible rate-limiting conversion C19 androgen form C18 estrogen. transcript expression has been detected rodent avian brains, especially limbic system, hypothalamus, preoptic nucleus, sexually dimorphic bed nucleus striata terminalis (BNST), hippocampus cerebellum. Gonadotropins such as luteinizing hormone (LH) follicle-stimulating (FSH) are usually elevated aromatase-deficient patients. These aromatase–deficient patients confirmed that estrogen exerts negative feedback both pituitary gland hypothalamus modulate levels gonadotropin secreted anterior pituitary.