Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

作者: Jonathan Welti , Sonja Loges , Stefanie Dimmeler , Peter Carmeliet

DOI: 10.1172/JCI70212

关键词: Angiogenic ProteinsAngiogenesisNeovascularizationFda approvalVEGF receptorsCancerOcular neovascularizationPharmacologyBiologyAntiangiogenic therapyCancer research

摘要: Four decades ago, angiogenesis was recognized as a therapeutic target for blocking cancer growth. Because of its importance, VEGF has been at the center stage antiangiogenic therapy. Now, several years after FDA approval an anti-VEGF antibody first agent, many patients with and ocular neovascularization have benefited from VEGF-targeted therapy; however, this anticancer strategy is challenged by insufficient efficacy, intrinsic refractoriness, resistance. Here, we examine recent discoveries new mechanisms underlying angiogenesis, discuss successes challenges current therapy, highlight emerging paradigms.

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