Lung cancer mortality in the German chromate industry, 1958 to 1998.

摘要: Objectives: We conducted a mortality study of two German chromate production facilities and evaluated possible dose-response relationships between hexavalent chromium exposure lung cancer. Methods: Mortality was followed-up through 1998 limited to those employed since each plant converted no-lime process. More than 12,000 urinalysis results levels were available, as smoking information. Results: All-cause indicated healthy worker effect (standardized ratio [SMR] = 0.80, 95% confidence interval [CI] 0.67–0.96); however, cancers appeared be increased (SMR 1.48, CI 0.93–2.25). No clear found in stratified analyses by duration employment time hire. On the basis urinary data, cancer risk elevated only highest group 2.09, 1.08–3.65). Conclusions: These data suggest threshold occupational on