Cloning of the Beta Amyloid Peptide Gene in Alzheimer’s Disease
作者： J. N. Octave , F. de Sauvage , A. F. Macq , J. M. Maloteaux , C. G. Rasool
DOI: 10.1007/978-3-642-73647-6_15
关键词: Gene 、 Senile plaques 、 BACE1-AS 、 P3 peptide 、 Amyloid precursor protein 、 cDNA library 、 Complementary DNA 、 Biochemistry of Alzheimer's disease 、 Genetics 、 Biology
摘要: We have isolated and sequenced clones from the brain cDNA libraries derived three patients with sporadic Alzheimer’s disease (AD). Our results indicate that ADβ-amyloid peptide (AD-BAPP) sequences which do not differ those found in BAPP cDNAs a normal fetus adult brain. noted sequence of non-AD partial by Goldgaber et al. differs our AD-B APP cDNAs. The inverted dinucleotide would translate into serine instead tyrosine at position 687 thereby create putative glycosylation site C-terminus postulated BAPP. Such difference might affect processing However, as only one brains among five human now reported, significance such heterogeneity is unclear.
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