Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis

摘要: A critical question in tuberculosis control is why some strains of Mycobacterium are preferentially associated with multiple drug resistances. We demonstrate that M. from Lineage 2 (East Asian lineage and Beijing sublineage) acquire resistances vitro more rapidly than 4 (Euro-American lineage) this higher rate can be attributed to a mutation rate. Moreover, the correlates well bacterial humans as determined by whole genome sequencing clinical isolates. Finally, using stochastic mathematical model, we observed differences predict substantially probability patients infected susceptible strain will harbor multidrug resistant bacteria at time diagnosis. These data suggest interventions prevent emergence should target treatment-related risk factors.