Total Skin Electron Beam Therapy in the Treatment of Mycosis Fungoides: A Review of Conventional and Low-Dose Regimens.

摘要: Abstract Mycosis fungoides (MF) is the most prevalent subtype of cutaneous T-cell lymphoma, which characterized by proliferation CD4 + T cells. While often an indolent disease, patients eventually develop progression from isolated patches to tumors and finally nodal or visceral involvement. Treatment choice largely based on disease burden, though prognostic factors such as stage, patient age, extracutaneous involvement must be taken into consideration. Radiotherapy represents one effective therapeutic modalities in treatment MF. Lymphocytes are exquisitely radiosensitive, excellent responses observed even with low doses radiation. Total skin electron beam therapy (TSEBT) a special technique that allows for homogenous irradiation entire skin. There well-documented radiation dose–response relationships achieving complete response. As such, TSEBT doses ≥ 30 Gy comprise current standard care. Although highly effective, experience recurrent after conventional-dose (≥ Gy) TSEBT. In addition, toxicity cumulatively dose dependent, there reluctance administer multiple courses Consequently, there has been renewed interest determining utility at lower total (≤ doses. Advantages low-total-dose (with per fraction) include shortened course, potential minimize risk adverse events, opportunity allow retreatment cases recurrence. This comprehensive review compares impact different dosing schemes clinical outcomes