作者: C. Curtet , J. P. Vuillez , G. Daniela , G. Aillet , A. Chetanneau
DOI: 10.1007/BF01268019
关键词: Indium 、 Nuclear medicine 、 Radioimmunoguided surgery 、 Colorectal cancer 、 Imaging phantom 、 Biodistribution 、 Radioactive source 、 Monoclonal antibody 、 Medicine 、 Gamma probe
摘要: The study was undertaken to define the potential use of indium 111 carcinoembryonic antigen-specific antibody labelled [CEA F(ab′)2] for radioimmunodetection colorectal carcinoma using an intraoperative hand-held gamma probe. a linear radioactive source allowed optimization physical characteristics. best results regarding sensitivity and resolution were obtained 5-mm thick tungsten alloy collimator. A simulation with liver phantom (22 MBq or 0.6 mCi) performed determine effect side scatter as opposed direct background showed that it is possible detect small targets (3.7 KBq 0.1 μCi) 4 cm from phantom. clinical ten patients tumours good uptake CEA-specific could be detected sufficient contrast in two when probe used. Results biodistribution after tumour fragment normal tissue countings well counter high (above 8 x 10−3 injected dose/g) tumour-to-normal ratios (between 2.5 20) five patients. markedly lower ratios. There no correlation between absolute count rates measured intraoperatively. This can attributed degradation depth resulting energy photopeak gamma-emitting111In.