Feasibility study of radioimmunoguided surgery of colorectal carcinomas using indium-111 CEA-specific monoclonal antibody

作者: C. Curtet , J. P. Vuillez , G. Daniela , G. Aillet , A. Chetanneau

DOI: 10.1007/BF01268019

关键词: IndiumNuclear medicineRadioimmunoguided surgeryColorectal cancerImaging phantomBiodistributionRadioactive sourceMonoclonal antibodyMedicineGamma probe

摘要: The study was undertaken to define the potential use of indium 111 carcinoembryonic antigen-specific antibody labelled [CEA F(ab′)2] for radioimmunodetection colorectal carcinoma using an intraoperative hand-held gamma probe. a linear radioactive source allowed optimization physical characteristics. best results regarding sensitivity and resolution were obtained 5-mm thick tungsten alloy collimator. A simulation with liver phantom (22 MBq or 0.6 mCi) performed determine effect side scatter as opposed direct background showed that it is possible detect small targets (3.7 KBq 0.1 μCi) 4 cm from phantom. clinical ten patients tumours good uptake CEA-specific could be detected sufficient contrast in two when probe used. Results biodistribution after tumour fragment normal tissue countings well counter high (above 8 x 10−3 injected dose/g) tumour-to-normal ratios (between 2.5 20) five patients. markedly lower ratios. There no correlation between absolute count rates measured intraoperatively. This can attributed degradation depth resulting energy photopeak gamma-emitting111In.

参考文章(14)
James A, Sardi A, Siddiqi Ma, Ferrara Pj, Thurston Mo, Mojzisik C, Farrar Wb, Hinkle G, Schlom J, Nieroda Ca, Staging of carcinoma of the breast using a hand-held gamma detecting probe and monoclonal antibody B72.3. Surgery gynecology & obstetrics. ,vol. 169, pp. 35- 40 ,(1989)
C. Kosciuczyk, D. Shealy, P. W. Doherty, T. W. Griffin, D. J. Hnatowich, R. L. Childs, M. Rusckowski, J. A. Mattis, Pharmacokinetics of an Indium-111-Labeled Monoclonal Antibody in Cancer Patients The Journal of Nuclear Medicine. ,vol. 26, pp. 849- 858 ,(1985)
D S Fairweather, A R Bradwell, P W Dykes, A T Vaughan, S F Watson-James, S Chandler, Improved tumour localisation using indium-111 labelled antibodies. BMJ. ,vol. 287, pp. 167- 170 ,(1983) , 10.1136/BMJ.287.6386.167
Brenda J Sickle-Santanello, Patric J O'Dwyer, Cathy Mojzisik, Steven E Tuttle, George H Hinkle, Michel Rousseau, Jeffrey Schlom, David Colcher, Marlin O Thurston, Carol Nieroda, Armando Sardi, William B Farrar, John P Minton, Edward W Martin, Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors. Diseases of The Colon & Rectum. ,vol. 30, pp. 761- 764 ,(1987) , 10.1007/BF02554623
Oladipo A. Oredipe, Rolf F. Barth, Steven E. Tuttle, Dianne M. Adams, Iveta Sautins, Donna M. Bucci, Cathy M. Mojzisik, George H. Hinkle, Scott Jewell, Zenon Steplewski, Marlin O. Thurston, Edward W. Martin, Limits of sensitivity for the radioimmunodetection of colon cancer by means of a hand held gamma probe International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. ,vol. 15, pp. 595- 603 ,(1988) , 10.1016/0883-2897(88)90049-9
Gary E. Krejcarek, Karen L. Tucker, Covalent attachment of chelating groups to macromolecules. Biochemical and Biophysical Research Communications. ,vol. 77, pp. 581- 585 ,(1977) , 10.1016/S0006-291X(77)80018-1
A. Chetanneau, P. A. Lehur, D. Ripoche, P. Peltier, J. C. Saccavini, J. P. Vuillez, N. Tournemaine, P. Thedrez, J. F. Chatal, Histological correlation of 17 prospective immunoscintigraphies of recurrences of colorectal carcinomas using indium-111-labeled anti-cea and(or) 19-9 monoclonal antibodies. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 15, pp. 302- 306 ,(1989) , 10.1007/BF00435470
Steven E. Tuttle, Scott D. Jewell, Cathy M. Mojzisir, George H. Hinkle, David Colcher, Jeffrey Schlom, Edward W. Martin, Intraoperative radioimmunolocalization of colorectal carcinoma with a hand-held gamma probe and MAb B72.3: Comparison of in vivo gamma probe counts with in vitro MAb radiolocalization International Journal of Cancer. ,vol. 42, pp. 352- 358 ,(1988) , 10.1002/IJC.2910420308