Niosomes as carriers for tretinoin: III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin

摘要: The influence of drug thermodynamic activity and niosome composition, size, lamellarity charge on the (trans)dermal delivery tretinoin (TRA) was studied. For this purpose, incorporated at saturated unsaturated concentrations in both multilamellar (MLV) unilamellar (UV) vesicular formulations using two different commercial mixtures alkyl polyglucosides: octyl-decyl polyglucoside decyl polyglucoside. Positively negatively charged were prepared either stearylamine or dicetylphosphate as a inducer. Niosomes made with polyoxyethylene (4) lauryl ether liposomes soy phosphatidylcholine also Vesicular characterised by transmission electron microscopy optical light polarized for vesicle formation morphology, dynamic laser scattering size distribution. effect incorporation its through newborn pig skin investigated vitro Franz cells, comparison formulation (RetinA®). amount delivered accumulated several layers detected HPLC. Overall, obtained results showed that cutaneous is strongly affected composition drug. In particular, small, niosomal formulations, which are tretinoin, have shown to give higher retention than formulation. Moreover, interactions between vesicles seem depend physico-chemical properties main component bilayer.