Dosing Recommendations for Pediatric Patients With Renal Impairment
作者： Amer Al‐Khouja , Kyunghun Park , Daijha J.C. Anderson , Caitlyn Young , Jian Wang
DOI: 10.1002/JCPH.1676
关键词: Drug toxicity 、 Clinical evidence 、 Clearance 、 Drug 、 Clinical study 、 Special populations 、 Intensive care medicine 、 Medicine 、 Dosing 、 Drug development
摘要: A treatment gap exists for pediatric patients with renal impairment. Alterations in clearance and metabolism of drugs render standard dosage regimens inappropriate may lead to drug toxicity, but these studies are not routinely conducted during development. The objective this study was examine the clinical evidence behind current impairment recommendations a dosing handbook. sources comparisons included handbook (Lexicomp), U.S. Food Drug Administration-approved manufacturer's labels, published literature. One hundred twenty-six Lexicomp had recommendations. Only 14% (18 126) referenced study, 15% labels (19 described specific renally impaired patients. Forty-two products information on dosing, 19 (45%) were case studies. When Lexicomp, followed adult label. Clinical does exist most widely used handbook, from label currently primary source information.
sci-hub.st 参考文章(98)
Ihab M. Wahba, Ali J. Olyaei, David Rozansky, William M. Bennett, Handling of Drugs in Children with Abnormal Renal Function Springer Berlin Heidelberg. pp. 1693- 1711 ,(2009) , 10.1007/978-3-540-76341-3_69
Erin R Stucky, Prevention of medication errors in the pediatric inpatient setting. Pediatrics. ,vol. 112, pp. 431- 436 ,(2003) , 10.1542/PEDS.112.2.431
David R. Newell, Andrew D. J. Pearson, Michael Cole, Stephen P. Lowis, Etoposide pharmacokinetics in children: the development and prospective validation of a dosing equation. Cancer Research. ,vol. 53, pp. 4881- 4889 ,(1993)
Isabel Porto, Eunice G. John, Jonathan Heilliczer, Removal of phenobarbital during continuous cycling peritoneal dialysis in a child Pharmacotherapy. ,vol. 17, pp. 832- 835 ,(1997) , 10.1002/J.1875-9114.1997.TB03766.X
Kim LR Brouwer, Lauren M Aleksunes, Barbara Brandys, George P Giacoia, Gregory Knipp, Viera Lukacova, Bernd Meibohm, Sanjay K Nigam, Michael Rieder, Saskia N de Wildt, Pediatric Transporter Working Group, Susan Abdel‐Rahman, Lauren M Aleksunse, Sharyn D Baker, Michael B Bolger, Barbara Brandys, Kim LR Brouwer, Kevin T Bush, Barbara Clancy, John M DeSesso, Jeffery Fisher, Tsuyoshi Fukuda, George P Giacoia, Richard Kim, Gregory Knipp, Gideon Koren, Grace S Lee, J Steven Leeder, Viera Lukacova, Bernd Meibohm, Tomoyuki Mizuno, Miriam G Mooij, Sanjay K Nigam, Michael Rieder, Matthias Schwab, Evita van de Steeg, Margaret MS Thomson, Aksana Vasilyeva, Alexander A Vinks, Saskia N de Wildt, Wei Wu, Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical Pharmacology & Therapeutics. ,vol. 98, pp. 266- 287 ,(2015) , 10.1002/CPT.176
Paul S. Lietman, Urs B. Schaad, George H. McCracken, John D. Nelson, Clinical pharmacology and efficacy of vancomycin in pediatric patients The Journal of Pediatrics. ,vol. 96, pp. 119- 126 ,(1980) , 10.1016/S0022-3476(80)80347-7
L. Carlson, M. P. Goren, D. A. Bush, J. C. Griener, R. Quigley, I. Tkaczewski, B. A. Kamen, S. D. Weitman, Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor Cancer Chemotherapy and Pharmacology. ,vol. 41, pp. 140- 146 ,(1997) , 10.1007/S002800050720
Lisa C Iacono, Denise Adams, Alan C Homans, Ann Guillot, Jeannine S McCune, Clinton F Stewart, Topotecan disposition in an anephric child. Journal of Pediatric Hematology Oncology. ,vol. 26, pp. 596- 600 ,(2004) , 10.1097/01.MPH.0000137368.27242.CA
W. Gordon Walker, C. Robert Cooke, Plasma aldosterone regulation in anephric man Kidney International. ,vol. 3, pp. 1- 5 ,(1973) , 10.1038/KI.1973.1
Jeffrey Saland, Patrick Leavey, Robert Bash, Eleonora Hansch, Gerald Arbus, Raymond Quigley, Effective removal of methotrexate by high-flux hemodialysis Pediatric Nephrology. ,vol. 17, pp. 825- 829 ,(2002) , 10.1007/S00467-002-0946-7