Spectroscopic and spectrofluorimetric studies on the interaction of irbesartan with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and iodine.
作者： K Ganesh , C Balraj , KP Elango , None
DOI: 10.1016/J.SAA.2011.05.022
关键词: Solvent effects 、 Raman spectroscopy 、 Photochemistry 、 Binding constant 、 Solvent 、 Proton NMR 、 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone 、 Stability constants of complexes 、 Fluorescence 、 Chemistry
摘要: Abstract Raman, UV–vis, 1H NMR, FT-IR, mass and fluorescence spectral techniques were employed to investigate the mechanism of interaction irbesartan (IRB) drug with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) iodine. Interaction IRB iodine yields triiodide ion its formation was confirmed by electronic Raman spectra. The peaks appeared in spectrum isolated product at 143, 113 76 cm−1 are assigned νas(I–I), νs(I–I) δ(I3−) respectively, presence I3− ion. DDQ found proceed through outer complex conversion CT complex. Formation constant (K), molar extinction coefficient (ɛ) thermodynamic properties ΔH#, ΔS# ΔG# determined discussed. Fluorescence quenching studies indicated that between acceptors spontaneous IRB–DDQ is be stronger than other system. Solvent variation binding increased an increase polarity medium.
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