Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions.

摘要: Since the discovery of two cyclooxygenase isoforms (COX-1, COX-2), efforts have been made to characterize roles played by these enzymes in regulation physiological functions, as well explore their involvement pathophysiology inflammatory disorders. In digestive tract, majority evidence has obtained at mucosal level, where both regulate various and contribute development neoplastic The role COX gut neuromuscular compartment, expression detected different species, is still unclear. However, characterization actions exerted COX-derived prostanoids on motility under investigation for many years, it becoming increasingly appreciated that mediators subserve complex regulatory patterns motility. More recently, several studies strengthened concept COX-1 COX-2 are involved modulation gastrointestinal activity normal conditions, changes activities occur presence disorders, including bowel diseases postoperative ileus. Despite a large body preclinical evidence, aimed translating findings into clinically relevant applications needed, an attempt identify novel therapeutic approaches treatment disorders associated with alterations. This review illustrates discusses current knowledge pathways conditions