Renoprotective effect of irbesartan in a rat model of gentamicin-induced nephrotoxicity: Role of oxidative stress.
作者： Hayder M. Al-Kuraishy , Ali I. Al-Gareeb , Marwa S. Al-Naimi
关键词: Malondialdehyde 、 Glutathione reductase 、 Oxidative stress 、 Irbesartan 、 Medicine 、 Creatinine 、 Nephrotoxicity 、 Renal physiology 、 Pharmacology 、 Angiotensin II
摘要: BACKGROUND The renin-angiotensin system (RAS) is essential in renal physiology; however, disturbance of the RAS one chief pathways involved injury. Dysregulation may result both glomerular and tubulointerstitial injuries through direct effects angiotensin II (Ang II) type 1 receptor. Irbesartan other Ang blockers have renoprotective effect reduction on inflammations. Therefore, aim present study was to demonstrate irbesartan gentamicin-induced nephrotoxicity rats concerning oxidative stress. MATERIALS AND METHODS Thirty Sprague-Dawley Male divided into three groups, Group I (10 rats) treated with distilled water, gentamicin, III gentamicin plus for 12 days. Blood urea, serum creatinine, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione reductase (GSH), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecules (KIM-1), cystatin-c were measured each group. RESULTS significantly reduced blood MDA, NGAL, KIM-1, P < 0.05. increases SOD 0.05 without significant elevation GSH levels. CONCLUSION has attenuation acute modulation stress antioxidant capacity rats.
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