Effect of continuous positive airway pressure therapy on aortic stiffness in patients with obstructive sleep apnea syndrome.

摘要: Objective: The most significant complications seen in patients with obstructive sleep apnea syndrome (OSAS) are associated the cardiovascular system. present study assessed aortic stiffness OSAS and evaluated effect of continuous positive airway pressure (CPAP) therapy on stiffness. Method: Twenty-four newly diagnosed, previously untreated, moderate or severe (apnea-hypopnea index > 15) a control group 17 healthy were included study. M-mode recordings ascending aorta taken from parasternal long axis by echocardiograhy, systolic diastolic diameters measured. Aortic elastic parameters, strain, distensibility calculated. Measurements repeated after 6 months CPAP compared baseline values. Results: In OSAS, group, strain (6.7%± 2.1% vs. 12.4%± 3.1%; P < 0.001) (2.8 ± 0.9 × 10−6 cm2 dyn−1 5.5 1.7 dyn−1; evidently lower, there was correlation between parameters AHI. After 6-month course therapy, increases observed (6.1%± 1.5% 7.3%± 1.7%; (2.5 0.7 3.1 OSAS. Conclusion: lower than patients, treatment provided improvement parameters. (ECHOCARDIOGRAPHY, Volume 26, November 2009)