Effect of cytokine genes and season of birth on personality
作者： M. V. Alfimova , V. E. Golimbet , G. I. Korovaitseva , T. V. Lezheiko , N. V. Kondrat’ev
DOI: 10.17116/JNEVRO20171179182-87
关键词: Temperament 、 Medicine 、 Novelty seeking 、 Genotype 、 Immunology 、 Minor allele frequency 、 Temperament and Character Inventory 、 Personality 、 Allele 、 Season of birth
摘要: Aim To evaluate the interaction effects of season birth and immune system genes on personality traits 'Novelty seeking' (NS) 'Self-directedness' (SD). Based results an influence brain processes, authors hypothesized that birth, which is relevant for phenotype, can contribute to development traits. Material methods NS SD were measured in 336 healthy volunteers, aged from 16 67 years, using Temperament Character Inventory (TCI-125). IL1B C3954T, IL4 C-589T, IL13 C1112T TNFA G-308A polymorphisms genotyped. Results An effect C-589T was found (F2,322=6.03, pcorr=0.011, η2=0.04). Carriers minor allele T, who born winter, had lower higher SD. There a nominal main genotype (F=5.44, p=0.020) as well, with scores carriers T compared CC genotype. Conclusion The suggest etiology characteristics share common genetic elements including IL-4.
sci-hub.st 参考文章(49)
C. R. Cloninger, T. Przybeck, D. M. Svrakic, R. Wetzel, Temperament and Character Inventory PsycTESTS Dataset. ,(2011) , 10.1037/T03902-000
Chih-Hung Ko, Ju-Yu Yen, Cheng-Chung Chen, Sue-Huei Chen, Kuanyi Wu, Cheng-Fang Yen, Tridimensional personality of adolescents with internet addiction and substance use experience. The Canadian Journal of Psychiatry. ,vol. 51, pp. 887- 894 ,(2006) , 10.1177/070674370605101404
Hyun-Jung Park, Hyun-Soo Shim, Kyungeh An, Angela Starkweather, Kyung Soo Kim, Insop Shim, IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations Mediators of Inflammation. ,vol. 2015, pp. 941413- 941413 ,(2015) , 10.1155/2015/941413
K Minhas, F Ahmed, M Ishaque, S Micheal, A Ahmed, IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients. Journal of Investigational Allergology and Clinical Immunology. ,vol. 23, pp. 107- 111 ,(2013)
Xaquin Castro Dopico, Marina Evangelou, Ricardo C. Ferreira, Hui Guo, Marcin L. Pekalski, Deborah J. Smyth, Nicholas Cooper, Oliver S. Burren, Anthony J. Fulford, Branwen J. Hennig, Andrew M. Prentice, Anette-G. Ziegler, Ezio Bonifacio, Chris Wallace, John A. Todd, Widespread seasonal gene expression reveals annual differences in human immunity and physiology Nature Communications. ,vol. 6, pp. 7000- 7000 ,(2015) , 10.1038/NCOMMS8000
F. POCIOT, J. MØLVIG, L. WOGENSEN, H. WORSAAE, J. NERUP, A Taql polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro European Journal of Clinical Investigation. ,vol. 22, pp. 396- 402 ,(1992) , 10.1111/J.1365-2362.1992.TB01480.X
James MacMurray, David E. Comings, Valerio Napolioni, The gene-immune-behavioral pathway: Gamma-interferon (IFN-γ) simultaneously coordinates susceptibility to infectious disease and harm avoidance behaviors Brain Behavior and Immunity. ,vol. 35, pp. 169- 175 ,(2014) , 10.1016/J.BBI.2013.09.012
Benjamin P. Chapman, Sarah Hampson, John Clarkin, Personality-informed interventions for healthy aging: conclusions from a National Institute on Aging work group. Developmental Psychology. ,vol. 50, pp. 1426- 1441 ,(2014) , 10.1037/A0034135
Morgan L. Moon, Jennifer J. Joesting, Neil A. Blevins, Marcus A. Lawson, Stephen J. Gainey, Albert E. Towers, Leslie K. McNeil, Gregory G. Freund, IL-4 Knock Out Mice Display Anxiety-Like Behavior Behavior Genetics. ,vol. 45, pp. 451- 460 ,(2015) , 10.1007/S10519-015-9714-X
Mark Schaller, Justin H. Park, The Behavioral Immune System (and Why It Matters) Current Directions in Psychological Science. ,vol. 20, pp. 99- 103 ,(2011) , 10.1177/0963721411402596