Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL

摘要: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype, and fewer than half of patients are cured with standard front-line therapy. To improve therapeutic options, better animal models that accurately mimic human DLBCL (hDLBCL) needed. Canine (cDLBCL), one cancers in veterinary oncology, morphologically similar to hDLBCL treated using chemotherapeutic protocols. With genomic technologies, it now possible molecularly evaluate dogs as a potential large-animal model for hDLBCL. We evaluated canine lymphomas (cBCLs) immunohistochemistry gene expression profiling. profiles were many ways hDLBCLs. For instance, subset had increased NF-κB pathway genes, mirroring activated (ABC)-type DLBCL. Furthermore, immunoglobulin heavy chain (IGH) ongoing mutation status, which correlated ABC/germinal center (GCB) cell origin hDLBCL, separated cBCL into two groups statistically different progression-free overall survival times. In contrast rarely expressed BCL6 MUM1/IRF4 by immunohistochemistry. Collectively, these studies identify molecular similarities introduce pet representative future studies, including clinical trials.