Randomized controlled clinical study of rhPDGF-BB + β-TCP versus HA + β-TCP for the treatment of infrabony periodontal defects: clinical and radiographic results.

摘要: Increased knowledge of specific cellular responses and functions has led to the development numerous treatment modalities based on use growth factors. This controlled clinical radiographic study aimed evaluate effectiveness recombinant human platelet-derived factor BB (rhPDGF-BB) + β-tricalcium phosphate (β-TCP) in infrabony defects compare it with hydroxyapatite (HA) β-TCP. A total 18 interproximal patients chronic periodontitis were included. The test group was treated by open flap debridement combination rhPDGF-BB β-TCP, while control along HA At 12 months, both groups showed a significant mean probing pocket depth (PPD) reduction gain attachment level (CAL). There statistically significantly greater PPD compared control. observed differences between baseline CAL at months found be groups. than that group. Radiographic linear bone improved Percent fill increased postsurgery rh-PDGF-BB β-TCP resulted higher comparison