Materials Established for Enantioselective Release of Chiral Compounds

作者: Huli Yu , Xueyong Yong , Junya Liang , Jianping Deng , Youping Wu

DOI: 10.1021/ACS.IECR.6B01031

关键词: Amino acidPolymerControlled releaseChemistryCombinatorial chemistryOrganic chemistryEnantiomerEnantioselective synthesis

摘要: The importance of chiral compounds has been widely recognized. Enantioselectively controlled release the desired enantiomer from a racemate while retarding other isomer provides novel route toward practical applications biologically molecules. Such processes may maximize efficacy minimizing dosage and frequency compounds. So far, exciting achievements have made in enantioselective (ESR), which can be classified into two main groups according to essential strategy: (1) interactions occurring between matrices (“enantioselective interaction” strategy); (2) recognizing sites inside molecular-imprinting polymers (MIPs; “key-to-lock” strategy). interest are not limited drugs, but also include important (e.g., amino acids). Based on our studies, this article reviews state-of-the-art techniques materials systems ESR. emphasis is...

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