Activation of REG family proteins in colitis
作者： Atle Van Beelen Granlund , Vidar Beisvag , Sverre H. Torp , Arnar Flatberg , Per Martin Kleveland
DOI: 10.3109/00365521.2011.605463
关键词: Biopsy 、 Ulcerative colitis 、 Intestinal mucosa 、 Immunology 、 Pancreatitis-Associated Proteins 、 Pseudomembranous colitis 、 Inflammatory bowel disease 、 Enterocolitis 、 Colitis 、 Medicine 、 Pathology
摘要: Abstract Aims. To do a genome-wide gene expression study of active and inactive ulcerative colitis Crohn's disease (inflammatory bowel – IBD) examine the most differentially expressed genes. As showed an extreme upregulation all regenerating islet-derived genes (REG proteins) in IBD, we further studied REGs on protein level as well non-IBD (pseudomembranous) colitis. Methods. Microarray analysis was done total 100 pinch biopsy samples from healthy controls patients with or Tissue IBD pseudomembranous were examined routine histology immunohistochemical for REGIα, REGIV, DEFA6, serotonin. Results. REG mRNAs up to 83 times overexpressed diseased mucosa compared individuals. REGIα REGIV at immunohistochemistry located different mucosal cell types. ...
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