Different mRNAs from the transforming region of highly oncogenic and non-oncogenic human adenoviruses.
作者： Anders Virtanen , Ulf Pettersson , Jean Michel Le Moullec , Pierre Tiollais , Michel Perricaudet
DOI: 10.1038/295705A0
关键词: In vitro 、 Biology 、 Virus 、 Cell biology 、 Protein biosynthesis 、 Embryo 、 Tissue culture 、 RNA splicing 、 Genome 、 Transcription (biology)
摘要: Only a fraction of the genome adenovirus, DNA tumour virus, is required for transformation in vitro1–4. The leftmost 11% genome, including two transcription units E1A and E1B, appear to be sufficient rat embryo cells tissue culture highly, weakly non-oncogenic adenovirus serotypes5,6. Various spliced mRNAs, orginating from transforming region, have been identified7-11 some cases corresponding protein products found12–14 but it unknown what renders serotypes highly oncogenic baby hamsters compared with others that are although able transform vitro. We studied mRNAs region serotype 12 (Ad12) hope finding novel which could account properties virus. previously failed find any differences between unit Ad12 type 2 (Ad2)15. Here we extended our analysis E1B show encodes different structures those encoded by Ad2.
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