Role of vitamin D receptor gene polymorphisms in pancreatic cancer: a case-control study in China.
作者： Lei Li , Feifei Shang , Weihui Zhang , Canhong Zhang , Junshan Li
DOI: 10.1007/S13277-015-3119-6
关键词: Restriction fragment length polymorphism 、 Pancreatic cancer 、 Biology 、 Internal medicine 、 Case-control study 、 Survival rate 、 Calcitriol receptor 、 Allele 、 Bioinformatics 、 Genotype 、 Population study 、 Oncology
摘要: The study was conducted to investigate the relationship between vitamin D receptor (VDR) gene rs2228570 and rs1544410 polymorphisms pancreatic cancer (PC). Two hundred fifty-eight PC patients 385 healthy controls were enrolled in this study. genotypes of assayed using polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) method. Univariate multivariate logistic regression analyses applied determine association PC-onset risk VDR polymorphisms. Contingency table analysis performed evaluate clinicopathological tumor features such as location, pathological differentiation, TNM classification PC. In rs2228570, T loci with allele could increase PC; rs1544410, G AG + GG decrease onset significantly. contingency indicated that correlated differentiation significantly, conclusion, incidence, significantly our population. So, have important implications incident rate survival
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