Chemo-enzymatic Synthesis of Novel β-Hydroxy-β-methylbutryric Acid (HMB)–Medium Chain Triacylglycerol (MCT) Complexes

摘要: β-Hydroxy-β-methylbutyrate (HMB) is reported to have ergogenic benefits such as reducing muscle wasting, promoting exercise performance and skeletal hypertrophy. When used a dietary feed, it has been found improve colostral milk fat the growth of piglets. Medium chain triacylglycerols (MCT) are good energy source they can be subjected β-oxidation in liver without being stored fats. animal HMB–MCT complexes stimulate produce leaner meat product. A high yield two-steps chemo-enzymatic pathway for synthesis developed. Ethyl HMB ester was first synthesized using chemical catalyst. Following that, transesterified with MCT by biocatalyst. Approximately 85 wt% achieved this two-step synthetic pathway. The reaction mechanism some parameters were also briefly elucidated.