A study of the properties, reactivity and anticancer activity of novel N- methylated-3-thiazolyl or 3-thienyl carbazoles and their Pd(II) and Pt(II) complexes

摘要: Abstract The synthesis and characterization of two hybrid N-methylated carbazole derivatives containing a thiazolyl or thienyl ring is reported. derivative has been also characterised by X-ray diffraction analysis. study its reactivity in front [MCl2(dmso)2] (M = Pd Pt) Na2[PdCl4] methanol allowed us to isolate characterize complexes. However, for the analogue, formation any Pd(II) Pt(II) complex was not detected, indicating that it less prone bind M(II) ions than analogue. Density Functional Theory (DFT) Time-Dependent (TD-DFT) calculations have carried out order rationalize influence nature group on electronic delocalization. Molecular mechanics show free rotation relation requires greater energy income Studies cytotoxic activity new compounds colon (HCT116) breast (MDA-MB231 MCF7) cancer cell lines ligand are most active agents series MCF7 line their potency higher cisplatin. In non-tumoral human skin fibroblast BJ line, all were toxic Their potential ability modify electrophoretic mobility pBluescript SK+ plasmid DNA act as inhibitors Topoisomerases I IIα cathepsin B investigated.