Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit
作者： Tomie Kawada , Takaharu Ishibashi , Hiroki Sasage , Kiminori Kato , Shoichi Imai
DOI: 10.1016/0306-3623(94)90160-0
关键词: Vasodilation 、 Chemistry 、 Sodium nitroprusside 、 Guinea pig 、 Methylene blue 、 Pharmacology 、 Blood vessel 、 Biochemistry 、 Intracellular 、 Nitric oxide 、 Phenylephrine
摘要: Abstract 1. The relaxation by nitroglycerin (GTN) and nitric oxide (NO) of aortic smooth muscles from rabbit rat contracted phenylephrine was inhibited LY 83583 (LY) methylene blue (MB) (the same applied to guinea-pig aorta), while the SNP not in rabbit. ANP inhibited. 2. All these agents produced concentration-dependent increases cyclic GMP. While GTN NO were MB, only those 3. Thus, behaved essentially similar indicating that substance is an inhibitor activation soluble guanylate cyclase NO-related vasodilators. It assumed that, like facilitated intracellular release
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