A Case of Multicentric Castleman's Disease Having Lung Lesion Successfully Treated with Humanized Anti-interleukin-6 Receptor Antibody, Tocilizumab
作者： Tomoaki Higuchi , Takashi Nakanishi , Kunio Takada , Mitsuyo Matsumoto , Makoto Okada
DOI: 10.3346/JKMS.2010.25.9.1364
关键词: Interleukin-6 receptor 、 Tocilizumab 、 Gastroenterology 、 Corticosteroid 、 Disease 、 Regimen 、 Pathology 、 Lung 、 Internal medicine 、 Medicine 、 Tacrolimus 、 Antibody
摘要: This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with lung lesion that was successfully treated an anti-interleukin-6 receptor antibody, tocilizumab in combination corticosteroid and tacrolimus. A 43-yr-old female abnormal shadows on chest X-ray referred to hospital for further examination. She diagnosed as having MCD based characteristic pathology inguinal lymph node, lesions, laboratory data, undifferentiated arthritis. Corticosteroid rituximab therapy did not fully ameliorate symptoms; thus, therapeutic regimen changed include tocilizumab, oral resulted clinical remission dose could be tapered. Tocilizumab tacrolimus may therefore beneficial treatment lesions associated MCD.
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