Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease

摘要: Oligodendrocytes are the myelinating cells of central nervous system that constitute about 5 to 10% total glial population. These responsible for myelin sheath production, which is essential not only rapid and efficient conduction electrical impulses along axons, but also preserving axonal integrity. arise from oligodendrocyte progenitor proliferate differentiate just before after birth, under a highly-regulated program. Both oligodendrocytes their precursors very susceptible injury by several mechanisms, including excitotoxic damage, oxidative stress inflammatory events. In this review, we will cover important aspects development regulatory mechanisms involved in process, some most pathways associated oligodendrogenesis. Moreover, address neurological disorders life journey present impairment function myelination during neurodevelopment, such as periventricular leukomalacia, hypoxia/ischemia hyperbilirubinemia turn can potentiate emergence neurodegenerative diseases like schizophrenia, multiple sclerosis Alzheimer's disease.