Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor.

作者: B. F. Roettger , D. Pinon , L. J. Miller , J. Yingling , C. Toledo

DOI:

关键词: InternalizationReceptorCholecystokinin receptorEnzyme-linked receptorCompetitive antagonistEndocrinologyCell biologyBiologyCholecystokininHomologous desensitizationInternal medicineAgonist

摘要: … observed after agonist occupation of several G protein-coupled receptors, which contributes … antagonist analogue of cholecystokinin (d-Tyr-Gly-[(Nle 28,31 ,d-Trp 30 )cholecystokinin-26–…

参考文章(22)
Fatih Ozcelebi, Rammohan V. Rao, Eileen Holicky, Benjamin J. Madden, Daniel J. McCormick, Laurence J. Miller, Phosphorylation of cholecystokinin receptors expressed on Chinese hamster ovary cells. Similarities and differences relative to native pancreatic acinar cell receptors. Journal of Biological Chemistry. ,vol. 271, pp. 3750- 3755 ,(1996) , 10.1074/JBC.271.7.3750
T. B. Chen, K. A. Kunkel, V. J. Lotti, R. S. L. Chang, Characterization of the binding of [3H]-(+/-)-L-364,718: a new potent, nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors. Molecular Pharmacology. ,vol. 30, pp. 212- 217 ,(1986)
Randall K. Pearson, Stephen P. Powers, Elizabeth M. Hadac, Herbert Gaisano, Laurence J. Miller, Establishment of a new short, protease-resistant, affinity labeling reagent for the cholecystokinin receptor Biochemical and Biophysical Research Communications. ,vol. 147, pp. 346- 353 ,(1987) , 10.1016/S0006-291X(87)80128-6
Elizabeth M. Hadac, Dilip V. Ghanekar, Eileen L. Holicky, Delia I. Pinon, Robert W. Dougherty, Laurence J. Miller, Relationship between native and recombinant cholecystokinin receptors: role of differential glycosylation. Pancreas. ,vol. 13, pp. 130- 139 ,(1996) , 10.1097/00006676-199608000-00003
Richard L. Huganir, Paul Greengardt, Regulation of neurotransmitter receptor desensitization by protein phosphorylation Neuron. ,vol. 5, pp. 555- 567 ,(1990) , 10.1016/0896-6273(90)90211-W
C. Nagain, M. C. Galas, M. F. Lignon, M. Rodriguez, J. Martinez, C. Rozé, Synthetic CCK8 analogs with antagonist activity on pancreatic receptors: in vivo study in the rat, compared to non-peptidic antagonists. Pancreas. ,vol. 6, pp. 275- 281 ,(1991) , 10.1097/00006676-199105000-00004
Martin H. Holtmann, Subhas Ganguli, Elizabeth M. Hadac, Vesile Dolu, Laurence J. Miller, Multiple Extracellular Loop Domains Contribute Critical Determinants for Agonist Binding and Activation of the Secretin Receptor Journal of Biological Chemistry. ,vol. 271, pp. 14944- 14949 ,(1996) , 10.1074/JBC.271.25.14944
J E Heuser, R G Anderson, Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. Journal of Cell Biology. ,vol. 108, pp. 389- 400 ,(1989) , 10.1083/JCB.108.2.389
H. McConnell, J. Owicki, J. Parce, D. Miller, G. Baxter, H. Wada, S Pitchford, The cytosensor microphysiometer: biological applications of silicon technology Science. ,vol. 257, pp. 1906- 1912 ,(1992) , 10.1126/SCIENCE.1329199
Peter J Munson, David Rodbard, None, Ligand: a versatile computerized approach for characterization of ligand-binding systems. Analytical Biochemistry. ,vol. 107, pp. 220- 239 ,(1980) , 10.1016/0003-2697(80)90515-1