Clearance of bile and trypsin in rat lungs following aspiration of human gastric fluid.
作者： Jason H. Leung , Jui-Chih Chang , Emily Foltz , Sadé M. Bell , Cinthia Pi
DOI: 10.3109/01902148.2016.1139213
关键词: Gastric fluid 、 Bronchoalveolar lavage 、 Pathology 、 Paracentesis 、 Lung 、 Trypsin 、 Medicine 、 Bile acid 、 Time frame
摘要: ABSTRACTPurpose: In the clinical setting, there is no reliable tool for diagnosing gastric aspiration. A potential way of fluid aspiration entails bronchoalveolar lavage (BAL) with subsequent examination BAL components that are exogenous to lungs. The objective this study was determine longevity bile and trypsin in lung, order provide an estimate time frame which assessment these might effectively be used as a measure Materials Methods: Human (0.5 mg/kg) infused right lung intubated male Fischer 344 rats (n = 30). Animals were sacrificed at specified times following experimentally induced aspiration, (BALF) collected. Bile concentrations analyzed by enzyme-linked chromatogenic method, concentration quantified using ELISA. Data ...
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