Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice

摘要: 1 Proteinase-activated receptor-2 (PAR2), a receptor activated by trypsin and tryptase, is abundantly expressed in the gastrointestinal tract including C-fiber terminal, might play role processing of visceral pain. In present study, we examined characterized roles PAR2 pancreatitis-related abdominal hyperalgesia/allodynia mice. 2 Caerulein, administered i.p. once, caused small increase sensitivity to stimulation with von Frey hairs, without causing pancreatitis, PAR2-knockout (KO) mice, but not wild-type (WT) mice. 3 Caerulein, given hourly six times total, more profound PAR2-KO as compared WT although no significant differences were detected severity pancreatitis between KO animals. 4 The PAR2-activating peptide, 2-furoyl-LIGRL-NH2, coadministered repeatedly caerulein abolished caerulein-evoked WT, PAR2-KO, mice. Repeated doses 2-furoyl-LIGRL-NH2 moderately attenuated caerulein-induced animals. 5 Our data from experiments using mice provide evidence that functions attenuate affecting itself, PAR2AP applied exogenously only antinociceptive also anti-inflammatory. British Journal Pharmacology (2006) 148, 54–60. doi:10.1038/sj.bjp.0706708