Paradoxical reactions elicited by diazepam in children with classic autism.

摘要: Administration of diazepam (10 mg i.m.) to seven children (two girls and five boys) affected by infantile autism elicited paradoxical behavioural responses. Mainly, anxiogenic effect, unsocialized aggressive behaviour explosive aggression were dramatically increased in comparison with the same symptoms present before after treatment. The results show for first time that benzodiazepines may elicit response autistic children. possible involvement an altered function at level GABA/benzodiazepine receptor complex is discussed.