44 - Drugs that affect lipid metabolism

作者: J.K. Aronson

DOI: 10.1016/S0378-6080(10)32044-7

关键词: Internal medicineMajor depressive disorderPlaceboPharmacologyEzetimibeHeartburnNauseaMedicineHMG-CoA reductaseLipid metabolismAdverse effect

摘要: Publisher Summary This chapter discusses the adverse effects of drugs that affect lipid metabolism, such as ezetimibe, fibrates, fish oils, 3-hydroxy-3-methyl-glutaryl -CoA reductase inhibitors, and nicotinic acid derivatives. Several studies use ezetimibe have shown few differences in rates events patients taking or placebo, later studies, including trials monotherapy. The psychiatric reactions been associated with statins, include depression, memory loss, confusion, aggressive reactions. reported to US Food Drug Administration for various lipid-modifying reviewed. omega-3 fatty supplements has studied 59 pregnant postpartum women major depressive disorder an 8-week double-blind, placebo-controlled trial. Of women, 13 mainly transient effects, dizziness, diarrhea, nausea, burping, difficulty swallowing capsules, feeling tired, heartburn/reflux, unpleasant breath/bad taste;the last twowerethe most common. statins other than those affecting liver muscle

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