Wilms' Tumor Gene 1 (WT1)--loaded dendritic cell immunotherapy in patients with uterine tumors: a phase I/II clinical trial.
作者： Stefaan W Van Gool , An Coosemans , Anke Vanderstraeten , Ignace Vergote , Philippe Moerman
DOI:
关键词: Oncology 、 Dendritic cell 、 Cancer research 、 Medicine 、 Internal medicine 、 Tumor antigen 、 Uterine sarcoma 、 Uterine cancer 、 Clinical trial 、 Wilms' tumor 、 Immunogenicity 、 Immunotherapy
摘要: Aim Treatment options are limited in uterine cancer, leading to a poor prognosis. Overexpression of Wilms' tumor gene 1 (WT1), the highest ranked antigen, is attractive for immunotherapy. Patients and methods Six pre-treated patients with cancer received four weekly vaccines autologous dendritic cells (DCs) electroporated WT1 mRNA. Safety, feasibility immunogenicity were assessed. In cases response, monthly booster vaccines. Results The technique was feasible. One patient had local allergic reaction. Three out Human Leucocyte Antigen-A2 (HLA-A2)-positive showed an oncological response; enrichment WT1-specific T-cells observed two them. Two HLA-A2-negative did not show or immunological response. Conclusion A first series six treated mRNA-electroporated DCs presented herein. Oncological responses supportive further research.
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