The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease

摘要: This chapter overviews studies that have relied on knockout mice to elucidate the role of several cytokines in pathogenesis experimental autoimmune encephalomyelitis, collagen II-induced arthritis, insulin-dependent diabetes mellitus, myasthenia gravis, and thyroiditis. A predominantly disease-promoting some (tumor necrosis factor, interferon-γ, interleukins-1, -4, -6, -12, -18), a disease-limiting other (interferon-β interleukin-10) been demonstrated. Thus, cytokine considerably helped clarify models disease. Most strikingly, mechanisms cell populations whose impacts were brought light by these belong almost exclusively innate immunity compartment. strengthens view disturbed recruitment is at least as important disease process antigen-specific reaction towards self.