Effect of N‐Acetylchito‐Oligosaccharides on Activation of Phagocytes
作者： Ko Suzuki , Akio Tokoro , Yoshio Okawa , Shigeo Suzuki , Masuko Suzuki
DOI: 10.1111/J.1348-0421.1986.TB03004.X
关键词: Muramyl dipeptide 、 Immunostimulant 、 Chemotaxis assay 、 Oligosaccharide 、 Ratón 、 Molecular biology 、 Biological activity 、 In vitro 、 Granulocyte 、 Biology 、 Microbiology
摘要: Four N-acetylchito-oligosaccharides, from tetra-N-acetylchitotetraose (NACOS-4) to hepta-N-acetylchitoheptaose (NACOS-7), were found increase the number of peritoneal exudate cells (PEC) in male BALB/c mice after 3 hr intraperitoneal administration 50 mg/kg each oligosaccharide. The attracted cells, consisting largely polymorphonuclear leukocytes (PMN), was proportional molecular weights administered oligosaccharides, except for NACOS-7 which displayed same activity as NACOS-6. In an vitro chemotaxis assay using normal mouse leukocytes, it that NACOS-6 stronger effects than muramyl dipeptide. PEC treated showed a higher active oxygen-generating activity. PMN peripheral blood also shown have enhanced vitro. possess strong candidacidal
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