The cerebrospinal fluid in subacute sclerosing panencephalitis and multiple sclerosis.

摘要: Publisher Summary Both subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS) are characterized by intrathecal synthesis of immunoglobulin G (IgG) within the central nervous system (CNS), giving rise to qualitative quantitative abnormalities cerebrospinal fluid (CSF) IgG. A feature both diseases is that electrophoresis shows oligoclonal bands—that is, bands IgG restricted heterogeneity—which either not present in serum or relatively less prominent. Because CNS such a SSPE MS, comparisons CSF abnormalities, particular IgG, may highlight aspects pathology each disease, especially because etiological agent specificity much synthesized well established, while etiology MS remains obscure.