Neuroprotective activity of hydroponic Teucrium polium following bilateral ovariectomy

作者: K. V. Simonyan , V. A. Chavushyan

DOI: 10.1007/S11011-014-9640-2

关键词: Long-term potentiationEstrogenNucleus basalisMetabolismTeucrium poliumAcid phosphataseHippocampus (mythology)Internal medicineBiologyEndocrinologyNeuroprotection

摘要: Ovariectomy is known as “surgical menopause” with decreased levels of estrogen in female rodents. Its reported risks and adverse effects include cognitive impairment. The action hydroponic Teucrium polium on nucleus basalis Meynert (bnM) neurons following 6 weeks ovariectomy was carried out. analysis spike activity observed by on-line selection the use a software package. Early late tetanic, − posttetanic potentiation depression to high frequency stimulation hippocampus were studied. complex averaged peri-event time histograms constructed. histochemical study Са2+-dependent acid phosphatase observed. In conditions administration, positive changes gain metabolism leading cellular survival revealed. administration elicited neurodegenerative bnM.

参考文章(52)
Ruiqing Zhu, Baofeng Ge, Bin Yang, Keming Chen, Yimin Wen, Jian Zhou, Guiqiu Han, Guozheng Cheng, Yuankun Zhai, None, Study on estrogenic effect of genistein and apigenin in vitro China Journal of Chinese Materia Medica. ,vol. 37, pp. 2317- 2322 ,(2012) , 10.4268/CJCMM20121528
Rui Liu, Tiantai Zhang, Haiguang Yang, Xi Lan, Jian Ying, Guanhua Du, The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice. Journal of Alzheimer's Disease. ,vol. 24, pp. 85- 100 ,(2011) , 10.3233/JAD-2010-101593
Kuresh A Youdim, M.Zeeshan Qaiser, David J Begley, Catherine A Rice-Evans, N.Joan Abbott, Flavonoid permeability across an in situ model of the blood-brain barrier Free Radical Biology and Medicine. ,vol. 36, pp. 592- 604 ,(2004) , 10.1016/J.FREERADBIOMED.2003.11.023
A. J. Rapkin, A. L. Akopians, Pathophysiology of premenstrual syndrome and premenstrual dysphoric disorder. Menopause International. ,vol. 18, pp. 52- 59 ,(2012) , 10.1258/MI.2012.012014
Xiao-Wu Xu, Chun Shi, Zhen-Quan He, Chun-Mei Ma, Wen-Hua Chen, Yi-Ping Shen, Qiang Guo, Chuan-Jun Shen, Jie Xu, Effects of Phytoestrogen on Mitochondrial Structure and Function of Hippocampal CA1 Region of Ovariectomized Rats Cellular and Molecular Neurobiology. ,vol. 28, pp. 875- 886 ,(2008) , 10.1007/S10571-008-9265-2
R. Liu, M. Gao, G.-F. Qiang, T.-T. Zhang, X. Lan, J. Ying, G.-H. Du, The anti-amnesic effects of luteolin against amyloid β25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit Neuroscience. ,vol. 162, pp. 1232- 1243 ,(2009) , 10.1016/J.NEUROSCIENCE.2009.05.009
N. A. Ibrahim, A. S. Shalaby, R. S. Farag, G. S. Elbaroty, S. M. Nofal, E. M. Hassan, Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruits growing in Egypt. Natural Product Research. ,vol. 22, pp. 537- 546 ,(2008) , 10.1080/14786410701592612
Fan-Shiu Tsai, Wen-Huang Peng, Wen-Hsin Wang, Chi-Rei Wu, Chia-Chang Hsieh, Yao-Tung Lin, Ifrim-Chen Feng, Ming-Tsuen Hsieh, Effects of luteolin on learning acquisition in rats: involvement of the central cholinergic system. Life Sciences. ,vol. 80, pp. 1692- 1698 ,(2007) , 10.1016/J.LFS.2007.01.055
Gabriele Losi, Giulia Puia, Giorgio Garzon, Maria C. de Vuono, Mario Baraldi, Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons European Journal of Pharmacology. ,vol. 502, pp. 41- 46 ,(2004) , 10.1016/J.EJPHAR.2004.08.043