Enhanced Brain Delivery of Amino Acids and Peptides Through the Use of Redox Targeting Systems

摘要: Many central diseases, including amino acid and neuropeptide deficiencies, are potentially treatable using replacement therapy. Unfortunately, delivery of the appropriate agents to nervous system is a highly complex undertaking due an interfacial barrier vascular derivative termed blood-brain (BBB).1–3 The cerebral microvasculature differs in several important respects from those capillaries present periphery. Firstly, endothelial cells which comprise microvessels tightly joined one another.4,5 This unique architecture prevents bulk movement materials between forces compounds diffuse directly through phospholipid cell membrane if they gain access brain parenchyma. Since only with sufficient affinity for lipid membranes will penetrate BBB, hydrophilic molecules, many drugs, excluded.6 Other distinguishing features that not fenestrated maintain vesicular transport relatively low activity. These functions substantially restrict generalized into CNS have clearly evolved protect delicate environment necessary optimal neural functioning.